Most pharmaceuticals sold today have their origin in a biochemistry laboratory. Drug discovery has traditionally started with a biochemical pathway implicated in a pathophysiological process. An ...

Two of the critical issues that arise when examining DNA microarray data are (1) determination of which genes best discriminate among the different types of tissue, and (2) characterization of ...

While microarray technology is broadening its applications in genomics and proteomics, the technique remains a vibrant contributor in the area of gene expression. Much of the overall developmental ...

Phase I and Pharmacologic Study of Oral ZD9331, A Novel Nonpolyglutamated Thymidylate Synthase Inhibitor, in Adult Patients With Solid Tumors ABSTRACT: Aberrant gene expression is critical for tumor ...

BUFFALO, N.Y. -- A multidisciplinary team of pharmaceutics and computer-science researchers at the University at Buffalo, one of very few teams in the nation applying DNA microarray technology in ...

Microarray technology has been applied to a variety of different fields to address fundamental research questions. The use of microarrays, or DNA chips, to study the gene expression profiles of ...

Students model how scientists use DNA microarrays to determine levels of gene expression in breast cancer patients, and then choose treatments based on what they learn. Normal-functioning DNA codes ...

The research community's rapid acceptance of microarrays notwithstanding, technical challenges remain. Biochip developers continue to grapple with these issues while upgrading their offerings and ...

A team of researchers from Roche (SIX: RO, ROG; OTCQX: RHHBY), including scientists from Roche Pharma Research and Early Development and Roche NimbleGen, reported inGenome Research (1) that they have ...

New Haven, Conn. — Yale University researcher Michael Snyder and his colleagues have created the first microchip able to analyze virtually all yeast proteins, the chemicals that carry out the ...