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改写教科书!《Cell》揭示促癌因子MYC竟能结合新生RNA,关闭R-loop/dsRNA ...
传统认知中,MYC是驱动癌细胞无限增殖的“总开关”——它作为转录因子,结合在DNA上,对大量基因的表达产生积极影响,形成肿瘤的特征性表达谱。除此之外,MYC还可以帮助癌细胞逃避免疫系统的监视:在胰腺癌模型中,敲除MYC能引发肿瘤消退,但这种效应在免疫 ...
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